Job Requisition R-194046 Preclinical and Translational PK

2 weeks ago

Mölndal, Västra Götaland, Sweden AstraZeneca Göteborg Full time

Do you have expertise in mathematical modelling and/or pharmacokinetics and pharmacodynamics? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for to be part of the development of future treatment within respiratory and immunology.

Our team is growing, and we now have two openings for highly skilled and passionate scientists with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Drug Metabolism and Pharmacokinetics (DMPK) team of project leads within the Early Respiratory and Immunology (R&I) therapeutic area at AstraZeneca in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality.

Early R&I is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and life-cycle management. At AstraZeneca we are proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity toward delivering candidate drugs into late-stage development.

What you'll do?

You have a true passion for science and will support our portfolio within the R&I therapeutic area. We believe that you have solid, hands-on experience of PKPD modeling and that you will be able to provide expert advice and interpretation of complex drug discovery data. You will deliver translational quantitative/PKPD input for a broad range of drug modalities from target identification to life-cycle management.

Main Duties and Responsibilities include:

  • Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
  • Inform and influence the design of studies, with PKPD in mind to answer relevant pharmacological questions and report results and interpretations to project teams and internal governance bodies
  • Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
  • Integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen. This is done in close collaboration with other functions (biologists, safety scientists, clinical pharmacologist and clinical pharmacometricians)
  • Communicate scientific progress to internal and external stakeholders

Depending on your background, experience and skills, your initial career level will be a Senior Scientist, Associate Principal Scientist or Principal Scientist.

Essential for the role

The successful candidate is expected to have a solid PKPD understanding and hands on experience of mathematical modelling (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, quantitative systems pharmacology (QSP) models).

  • PhD or equivalent in relevant field, with a focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
  • Hands-on experience with modelling software (e.g. Phoenix WinNonlin, Matlab, Monolix, R, NONMEM, or similar)
  • Proven scientific leadership and ability to mentor junior colleagues
  • Experience in project leadership and collaborative mindset
  • Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts
  • Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
  • Proactive and excellent communication skills

Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Work policy

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next?

This is an exciting opportunity for a talented modeller to join a strong team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the wonderful city of Gothenburg, Sweden. If you are ready to make a difference - apply today, and we'll make it happen together

We welcome your application until


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