Computational Biology Specialist

13 hours ago


Stockholm, Stockholm, Sweden Chiesi Farmaceutici S.p.A. Full time

Company Overview

At Chiesi, we are committed to improving people's quality of life by acting responsibly towards society and the environment. As a leading international research-focused pharmaceutical and healthcare group, we operate in 31 countries with over 7,000 employees.

We are proud to be the largest global pharmaceutical group to be awarded B Corp Certification, recognizing our high social and environmental standards. Our strong set of shared Values and Behaviors guides us in achieving success through attracting and retaining top talent who live and breathe our values and behaviors.

Our Research & Development team represents a fundamental asset for the business, divided into integrated functional areas focusing on pipeline projects including discovery and preclinical research, global technical development, drug delivery technology, clinical development, regulatory affairs, pharmacovigilance, intellectual property, quality assurance, R&D project and portfolio management.

Job Responsibilities

As a Bioinformatics Lead, you will be responsible for providing bioinformatic expertise to address various biological questions by analyzing and interpreting data, generating reports and building systematic internal data repositories.

  • Conduct omics analyses towards target identification and drug mode of action characterization with emphasis on transcriptomic (scRNA-seq), genomic (WGS, WES), and proteomic (MS, Olink) data, connected with patient strata and clinical data.
  • Design, build and monitor analysis pipelines of molecular data and omic data using cloud computing solutions and code repositories.
  • Perform initial quality control checks and downstream analysis on data coming from -omics studies.
  • Perform multi-omic data integration approaches, network analysis, and pathway-level statistical analysis to generate new hypotheses and collaborate with scientists on data mining and guiding experimental design.
  • Collect, QC and homogenize public data sets towards their analysis and integration with internally-generated data, provide input to systematic multi-omic data repository creation and management towards drug repositioning.
  • Coordinate and oversee data analysis with external service providers.

Requirements:

  • PhD in bioinformatics and/or computational biology, with a strong biological/medical background, and minimum of 5 years' post-graduate experience.
  • Proficiency in analyzing NGS and single-cell analysis and subcellular analysis and other 'omics' data using statistical programming languages.
  • Demonstrated track record of applying bioinformatic analysis, including machine learning techniques and network biology, to integrate and analyze omic and clinical data, preferably within respiratory drug development.
  • Broad understanding of drug discovery and development, particularly early and late-stage development.
  • Strong publication record as a leading author.

Why Work with Us

We offer a dynamic, fast-growing, challenging and friendly environment where we invest in continuous training, learning and development. We strive to promote and satisfy development needs, paying particular attention to the quality of our working environment and to collective well-being.



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