Postdoctoral position in single-cell RNA sequencing of infecting bacteria
1 month ago
Project description
Single bacterial genomics and transcriptomics holds a great promise of improving our understanding of the microbiology world, discovering new enzymatic activities, or identifying the antibiotic resistance amongst others. Bacterial populations exhibit significant heterogeneity, allowing distinct cell subgroups to thrive in diverse environments. This environmentally induced heterogeneity prompts bacteria to respond through unique transcriptional programs, posing substantial experimental challenges in assaying individual cells accurately. Recent advancements in single-cell techniques, particularly single-cell RNA sequencing (scRNA-seq), offer a powerful means to unravel cellular heterogeneity during infections and discern subpopulation variations that influence individual cell outcomes. However, current bacterial scRNA-seq methods suffer from the low number of cells being sequenced and the low number of transcripts detected in each cell. Therefore, our primary objective is two fold: i) to develop a novel high-throughput RNA sequencing technology tailored for single bacterial cells, and ii) to apply it on a model system (Yersinia sp.) in order to better understand the gene expression dynamics that drive cell response, adaptation and evolution.
Working tasks
The postdoctoral fellow is expected to engage actively in research, participate in the design and execution of experiments, data analysis development. Lead the establishment of new methods in the lab, as well as to present and publish results to broader audiences. The candidate is also expected to participate in research-related activities within the research group such as seminars, group meetings, journal clubs, national and/or international conferences, etc.
Qualifications
To be appointed under the postdoctoral agreement, the postdoctoral fellow is required to have completed a doctoral degree or a foreign degree deemed equivalent to a doctoral degree. This qualification requirements must be fulfilled no later than at the time of the appointment decision.
To be appointed under the postdoctoral agreement, priority should be given to candidates who completed their doctoral degree, according to what is stipulated in the paragraph above, no later than three years prior. If there are special reasons, candidates who completed their doctoral degree prior to that may also be eligible. Special reasons include absence due to illness, parental leave, appointments of trust in trade union organisations, military service, or similar circumstances, as well as clinical practice or other forms of appointment/assignment relevant to the subject area. Postdoctoral fellows who are to teach or supervise must have taken relevant courses in teaching and learning in higher education.”
The candidate must have a doctoral degree or a foreign degree deemed equivalent to a doctoral degree, in Biochemistry, Molecular Biology, or Microbiology. The ideal candidate should be tech-savvy, proficient in standard molecular biology, biochemistry, and handling cultures of various microbial species. Prior experience in droplet microfluidics systems is not requires but could be useful. A training in microscopy and flow cytometry is beneficial. The post-doctoral candidate should have at least some prior experience in transcriptomic or genomic library preparation and sequencing. Bioinformatic knowledge and experience in programming languages such as Python, Perl, or R is desirable.
We seek individuals who are highly motivated and demonstrate a strong commitment to research excellence. Efficient communication skills for interaction with senior colleagues and peers, and ability to work effectively in a team environment.
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Umeå, Västerbotten, Sweden Umeå University Full timeProject DescriptionSingle bacterial genomics and transcriptomics play a crucial role in advancing our knowledge of the microbiology realm, discovering new enzymatic activities, and identifying antibiotic resistance, among other breakthroughs.Bacterial populations display significant diversity, enabling different cell subgroups to thrive in various settings....
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