Postdoctoral researcher
1 month ago
Project description
and working tasksAutophagy is an evolutionarily conserved self-eating process mainly purposed to eliminate or recycle dysfunctional cellular organelles or unused proteins. Autophagy plays an important role in development and ageing and has been associated with diverse human diseases including cancer, neurodegeneration and pathogen infection. Emerging evidence shows that autophagy machinery also plays a role in several autophagy-independent processes. These “noncanonical” autophagy (NCA) pathways occur independent of part of the core autophagy machinery and play an important role in immune regulation and inflammation, modulation of the host-pathogen interaction, regulation of neuronal signaling and anti-cancer immunity.
Using a combination of cell biology, structural biology and chemical genetic approaches, we have elucidated fundamental mechanisms underlying autophagosome formation. Our laboratory has elaborated a novel mode of action for virulent bacteria (Legionella pneumophila, Vibrio cholerae) affecting host autophagy (eLife 2017, JCS 2021, JCB2022). We have identified novel chemotypes for autophagy modulation and new cellular pathways involved in autophagy regulation (Angew Chem 2017, Nat Chem Biol 2019, Autophagy 2021, Angew Chem 2022). Recently, we have made new findings in NCA. We identified the novel lysosomal targeting compound Inducin and ESCRT-III targeting compound Tantalosin that induce NCA (ChemBioChem 2023, PNAS 2024). We discovered a new pathway, the sphingomyelin-TECPR1 axis and TECPR1-ATG5–ATG12 as an alternative E3-like ligase for ATG8 lipidation in NCA (EMBO Rep 2023). This project will combine biochemical, cell biological and novel chemical approaches to understand molecular mechanisms of canonical and noncanonical autophagy. The techniques used in the project include protein expression and purification, protein/peptide synthesis, biochemical characterization, in vitro reconstitution, cell imaging, western blotting, and knock-out/down.
Qualifications
To be appointed under the postdoctoral agreement, the postdoctoral fellow is required to have completed a doctoral degree or a foreign degree deemed equivalent to a doctoral degree. This qualification requirements must be fulfilled no later than at the time of the appointment decision.
To be appointed under the postdoctoral agreement, priority should be given to candidates who completed their doctoral degree, according to what is stipulated in the paragraph above, no later than three years prior. If there are special reasons, candidates who completed their doctoral degree prior to that may also be eligible. Special reasons include absence due to illness, parental leave, appointments of trust in trade union organisations, military service, or similar circumstances, as well as clinical practice or other forms of appointment/assignment relevant to the subject area. Postdoctoral fellows who are to teach or supervise must have taken relevant courses in teaching and learning in higher education.
Doctoral degree in biochemistry, cell biology, chemical biology, molecular biology, or in another relevant field.
Additional requirements are:
Good command of written and spoken English.
Merits:
Experiences in protein expression and purification, protein/peptide chemistry, molecular cloning, membrane biochemistry, in vitro reconstitution, cell imaging, western blotting, and/or knock-out/down, as is a good record of research publication.
We seek a candidate who independently further their own studies but also be in close collaboration with other members of the team. Independence and good ability to collaborate are therefore requirements.
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