Embryonic Cell Fate Expert

15 hours ago


Stockholm, Stockholm, Sweden Karlstad University Full time

We are seeking a highly motivated postdoctoral researcher to join our ERC-funded project at Karolinska Institutet, where we aim to resolve embryonic cell fate lineages with unprecedented resolution.

Project Overview

The project involves further optimizing and automating in utero nano-injection methods to target multipotent cells at early developmental stages, enabling precise manipulation and lineage tracing of germ layer derivatives. We will use existing bioinformatic pipelines to resolve embryonic lineages based on embryonic barcoding and employ advanced techniques such as single-cell RNA sequencing and spatial transcriptomics to reconstruct lineage trees and uncover cell fate dynamics.

The successful candidate will work in a collaborative, interdisciplinary environment with access to world-class facilities and expertise in developmental biology, genetics, and computational analysis.

Responsibilities
  • Optimize and automate in utero nano-injection methods to target multipotent cells at early developmental stages.
  • Collaborate with our interdisciplinary team to reconstruct lineage trees and uncover cell fate dynamics using advanced techniques such as single-cell RNA sequencing and spatial transcriptomics.
  • Use existing bioinformatic pipelines to resolve embryonic lineages based on embryonic barcoding.
Requirements

To be eligible for this position, you should have a PhD degree in developmental biology, transcriptomics, or a similar relevant research area. Additionally, you should possess skills in RNA omics, bioinformatics, mouse work (Felasa certification), especially surgery, embryonic dissections, and/or programming/engineering of robotic equipment.



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