Postdoctoral Researcher in Innate Immunity
1 month ago
Project Overview
Innate immune cells are constantly sensing their environment and responding to pathogen invasion. This process involves changes in their transcriptional and proteomic landscapes. Microproteins, small proteins encoded by short Open Reading Frames, play regulatory roles in diverse cellular pathways. Our project aims to identify microproteins in innate immune cells involved in immune processes using a combination of bioinformatic, ribosome profiling, and proteomic approaches.
Work Tasks
The responsibilities associated with this position include:
- Bioinformatic analysis of transcriptomic datasets and protein sequences from publicly available datasets and own datasets.
- Generation of ribosome profiling datasets for resting and activated innate immune cells to identify open reading frames with coding potential.
- Identification of newly identified open reading frames at the protein level using proteomic approaches.
Eligibility
A person who has been awarded a doctorate or a foreign qualification deemed to be the equivalent of a doctorate in natural sciences is eligible for appointment as a postdoctoral researcher. This eligibility requirement must be met no later than the time at which the appointment decision is made.
Required Skills
The ideal candidate should have experience in at least one of the following techniques:
- Sample preparation and/or bioinformatic analysis of transcriptomic data (preferably ribosome profiling).
- Preparation and analysis of mass spectrometry samples.
Desirable Skills
Experience working with primary immune cells and tissue culture is desirable. The candidate should also have an interest in innate immunity or immunology and be willing to work and develop in an interdisciplinary environment and work closely as part of a team.
Appointment Details
The appointment is a full-time, fixed-term position for 2 years in accordance with the terms of contract for fixed-term employment as a postdoctoral researcher from 1 February 2022.
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