PhD Position in Cancer Biology

13 hours ago


Gothenburg, Västra Götaland, Sweden Göteborgs Universitet Full time
About the Project
Despite advances in treatment and genetic classification of DLBCL, between 30 to 40% of patients still die from the disease. This heterogeneity can likely not be explained by genetic changes alone. Our research group has found over-expression of interferon-stimulated proteins, which previously have not been described in DLBCL, appearing to affect both prognosis and response to treatment. We aim to investigate the prognostic value of digital immunohistochemical analysis of these proteins in large patient materials.

Research Objectives
The specific objectives of this project are:

- To investigate the prognostic value of digital immunohistochemical analysis of interferon-stimulated proteins in large patient materials.
- To investigate the functional role of these proteins in DLBCL using in vitro and in vivo models.
- To investigate the therapeutic effect of blocking/downregulation of such genes/proteins, as proof-of-concept in vivo, in DLBCL mouse models.

Responsibilities
You will be responsible for designing and conducting experiments, collecting and analyzing data, and presenting results through academic papers and presentations. You will also contribute to the writing of grant proposals and other research-related tasks.

Requirements
To be successful in this position, you will need to have a strong background in molecular biology, cell culture, and bioinformatics. Experience with experimental studies, histological methods, RNA/protein preparation, and knowledge of PCR and RNA sequencing are highly advantageous. Additionally, you should be proficient in spoken and written English, as well as have excellent communication and teamwork skills.

What We Offer
As a doctoral student at Göteborgs Universitet, you will receive a competitive salary, comprehensive health insurance, and access to state-of-the-art research facilities. You will also have the opportunity to participate in international conferences and collaborate with renowned researchers in the field. Moreover, you will contribute to the University's commitment to diversity, equity, and inclusion by working in a collaborative and inclusive environment.

Timeline
The project will commence upon admission, with the following timeline:

- Initial period of three months: Literature review, experimental design, and preparation of reagents and equipment.
- Next nine months: Conducting experiments, collecting and analyzing data, and presenting preliminary results.
- Final six months: Writing and submitting manuscripts, preparing grant proposals, and disseminating findings through presentations and workshops.

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