Postdoctoral Researcher

7 days ago


Solna Municipality, Sweden Karolinska Institutet Full time
Research Opportunity

We are seeking a highly motivated Postdoctoral Researcher to join our research group at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm. Our team is focused on understanding the molecular mechanisms defining the transcriptomic and epigenomic states of oligodendrocyte lineage cells, with the aim to design epigenetic-based therapies to prevent and treat neuroinflammation in demyelinating diseases.

Research Group

Our research group has a strong track record of performing single-cell/spatial omics studies, identifying cell states within the oligodendrocyte lineage in development and disease. We have recently made significant findings suggesting that oligodendrocyte lineage cells may present other functional properties than previously thought, transitioning to disease-associated states. Our results also suggest that single nucleotide polymorphisms (SNPs) associated with multiple sclerosis susceptibility may be operational in oligodendrocyte lineage cells.

Project Description

The successful candidate will play a leading role in a limited-term (5 years) full-time research project funded by the European Research Council Advanced Grant, focused on studying the functional role of single nucleotide polymorphisms in the oligodendroglia lineage and its implication in multiple sclerosis. The multidisciplinary project involves in-vivo work, master molecular biology, master-cell culture techniques, flow cytometry/cell sorting, and single-cell & spatial omics.

Requirements
  • PhD in medical sciences, immunology, or neurosciences, or equivalent
  • Previous research experience in a multidisciplinary international environment in at least one of the areas listed below:
    • Experience in neuroimmunology and/or immune diseases, in particular, animal models of multiple sclerosis (with a FELASA certificate)
    • Experience in multiparametric flow cytometry/cell sorting
    • Culturing human pluripotent stem cell lines and mouse cell lines, differentiation to neural lineages, and cell transplantation
    • Molecular biology techniques
    • Confocal microscopy and histology
What We Offer

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. This Unit has presently eight research groups, focused on omics technologies and several aspects of development, stem cell biology, neuroscience, and cancer, providing a unique critical mass and expertise, and vibrant scientific environment.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holidays and a generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.



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