Doctoral (PhD) student position in cancer immunotherapy
2 days ago
Doctoral (PhD) student position in cancer immunotherapy
Do you want to contribute to improving human health?
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The research group
Associate Professor Dr Mattias Carlsten M.D. Ph.D. is heading a translational research group at Karolinska Institutet (KI) with close connection to the medical unit Cell Therapy and Allogeneic Stem Cell Transplantation (CAST) at the Karolinska University Hospital. The group focuses on studying how NK cells can be utilized to treat cancer. More specifically, the group focuses on understanding basic biology and how to genetically engineer NK cells to improve their in vivo persistence and homing to the tumor for enhanced anti-tumor efficacy.
The doctoral student project and the duties of the doctoral student
This project will focus on the development of CRISPR-based approaches to genetically introduce or remove molecules/elements that can augment the anti-tumor potential of NK cells. The overall goal is to establish proof-of-concept for in vivo editing of NK cells for augmented anti-tumor efficacy. The student will address the role of introducing CARs and supporting cytokines via homology-directed end joining (HDR) for redirected tumor cell targeting. The project will involve various cellular and molecular biology techniques and assays such as flow cytometry, electroporation, and ELISA.
What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. As a doctoral student, you will be offered an individual research project, a well-educated supervisor, and opportunities for international exchanges.
Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements:
A) General eligibility requirement:
- Have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
- Have satisfied the requirements for courses comprising at least 240 credits, with at least 60 credits awarded in the advanced/second-cycle/master level.
B) Specific eligibility requirement: Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
We are seeking a highly talented individual who holds a Medical Doctor degree with experience in cell and/or gene therapy. The student should have a background in immunology and cell signaling, with critical merits in running immunology assays and conducting cell culture work.
Terms and conditions
The doctoral student will be employed on a doctoral studentship for a maximum of 4 years full-time.
Application process
Submit your application and supporting documents through the Varbi recruitment system. Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Documents certifying your general and specific eligibility
Selection
A selection will be made among eligible applicants based on the ability to benefit from doctoral education.
Want to make a difference? Join us and contribute to better health for all
Type of employment: PhD placement
Contract type: Full time
Number of positions: 1
City: Stockholm
Country: Sweden
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