Senior Scientist Bioscience Cardiovascular
5 days ago
Senior Scientist Bioscience Cardiovascular - AstraZeneca - Gothenburg - 12-month consultancy assignment
Senior Scientist, In Vitro Cardiovascular Biology
Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life-changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases
At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future - here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.
CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular-, chronic kidney- and metabolic diseases and delivering candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides and peptides.
We are now recruiting a Senior Scientist with expertise in cardiovascular biology to join the Bioscience Cardiovascular in vitro team within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.
What you'll do:
As a Senior Scientist, you will play a key role in driving science and projects within the cardiovascular area forward. This is a lab-based role where you will explore novel drug targets with key in vitro data. Collaboration is critical for successful delivery of drug projects, and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. You will work with in vitro biology using cell lines, pluripotent stem cells (PSC) and primary cardiovascular cells, along with molecular and functional biology techniques. You will have the opportunity to try novel techniques and ideas required for progressing the existing portfolio and novel science. Responsibilities include:
- Independently design, develop and run in vitro studies and assays for target identification and validation
- Work with molecular biology methods, imaging and assays for functional readouts such as contractility and cardiac metabolism
- Contribute to communications of scientific findings through publications in scientific journals and at meetings
- Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared
Essential for the role:
* PhD or master's degree in biology, pharmacology, cardiovascular disease or similar
* Strong experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays within the cardiovascular area
* Experience in handling and manipulating relevant PSC cells and primary human and animal cardiac cell types, including cardiomyocytes
* Excellent English communication skills, both spoken and in writing
Desirable for the role:
* Experience with cardiomyocyte biology and function in healthy and diseased systems
* Background in drug discovery and development in the pharmaceutical industry
* Background in Vivo and in Vitro
What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you, but you are looking for a new position, please contact us for a confidential discussion on your career.
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