Preclinical Principal Scientist- Chiesi

Are you a communicative and driven Principal Scientist with solid experience in ATMPs, in vivo studies, and collaboration with CROs? Do you want to join a growing preclinical team and contribute to a cutting-edge gene editing program where your expertise truly makes a difference? Chiesi is now recruiting a Principal Scientist to join their R&D organization. In this role, you will be a key member of the Chiesi Global Rare Disease preclinical team, playing a central part in the delivery of an innovative gene editing project. About the role The candidate will lead the design, execution, and interpretation of key in vivo non-clinical studies and provide scientific oversight of outsourced work performed by contract research organisations (CROs). These studies will include preliminary proof-of-concept experiments in established mouse disease models, dose-range finding studies, in-depth PK/PD modelling, and GLP-compliant safety and tolerability studies supporting IND-enabling packages. As a core member of the extended project team, the candidate will collaborate closely with preclinical, analytical, and discovery colleagues to drive this high-impact program forward. Key responsibilities include: • Identification of suitable CROs, contributing to RFP design, and developing Statements of Work • Managing relationships with CROs and external project partners • Designing, executing, and overseeing in vivo and PK/PD studies in relevant animal models • Designing, executing, and overseeing pivotal non-clinical GLP toxicology studies to support regulatory submissions • Supporting sample analysis and contributing to next-generation sequencing evaluation of derived tissues • Delivering clear summaries and interpretations of study data, including scientific impact and implications • Supporting the drafting of study reports for future regulatory filings • Liaising with key opinion leaders, project partners, and external consultants as needed Your Profile We are seeking a Principal Scientist with 5–7 years of experience gained through a combination of relevant post-doctoral academic and industry roles, including hands-on work with advanced therapeutic medicinal products (ATMPs), ideally in the field of Gene Editing. Requirements: • PhD in Molecular Biology, Pharmacology, or a related discipline • Proven experience developing animal disease models and conducting in vivo studies in both murine and non-human primate species • Strong skills in in vivo data interpretation, analysis and report preparation • Demonstrated experience managing and overseeing contract research organisations (CROs) • Experience contributing to regulatory documentation and/or participating in interactions with regulatory authorities • Ability to work independently, meet defined milestones, and operate effectively within a matrixed organisation • Solid working knowledge of relevant ICH, EMA and FDA guidelines We highly value experience with next-generation sequencing (NGS) technologies, such as Illumina or equivalent platforms. Skills in computational analysis of NGS data sets are also considered strong merits. To succeed in this role, you demonstrate strong verbal and written fluency in English, and you communicate clearly and effectively in both technical and collaborative contexts. As a person, you are results-driven and take initiative to move work forward. You collaborate easily with others, communicate clearly, and plan your tasks efficiently to deliver high-quality outcomes. The role is primarily based in Stockholm, Sweden, with the possibility of remote work from other European locations depending on individual circumstances. Contact In this recruitment, Chiesi is collaborating with Mpya Sci & Tech. For questions about the position, you are warmly welcome to contact the Recruitment Consultant, Britta Granath, at 073-96 44 221 or via britta.granath@mpyascitech.com. We are conducting an ongoing selection process, so don't delay your application, as the position may be filled before the final application date. To apply for the position, visit www.mpyascitech.com, no later than January 7. Looking forward to your application About Chiesi Chiesi is a family-owned research-focused international pharmaceutical company based in Parma and with more than 7.500 employees worldwide. We have established a strong heritage in delivering innovative pharmaceutical solutions to people living with respiratory, cardiovascular and rare diseases. Chiesi R&D sites are located in Italy, France, US, Canada, China, UK, and Sweden. In addition, as a B-corp certified benefit corporation, Chiesi is highly committed to sustainability and supporting the society. For more information, please visit: www.chiesipharma.com Chiesi Global Rare Diseases (GRD) business unit, established in 2020 with headquarters in Boston, is focused on research, development and commercialization of treatments and patient support services for rare and ultra-rare disorders. Chiesi GRD is now hiring both in Sweden and worldwide to support these programs. GRD recently entered a global strategic partnership with the US-based gene editing company Arbor to develop novel rare disease gene editing programmes. Learn more at: www.chiesi.com/en/rare-disease-gene-editing-partnership-chiesi-arbor