PhD position in Microbiology

2 weeks ago

Uppsala, Uppsala, Sweden Uppsala universitet Full time

Uppsala University, Department of Medical Biochemistry and Microbiology

Organisation/Company: Uppsala universitet

Department: Uppsala University, Department of Medical Biochemistry and Microbiology

Research Field: Biological sciences, Medical sciences

Researcher Profile: First Stage Researcher (R1)

Country: Sweden

Application Deadline: 30 Apr 2025 - 21:59 (UTC)

Type of Contract: Temporary

Job Status: Full-time

Is the job funded through the EU Research Framework Programme? Horizon 2020

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Department of Medical Biochemistry and Microbiology (IMBIM) at Uppsala University provides a broad international environment for research and teaching. Research at IMBIM broadly spans the areas of biochemistry, cell and molecular biology, tumour biology, comparative genetics, functional genomics, immunology, bacteriology, and virology. The research is essentially of fundamental nature, but with relevance and application in health and disease in both animals and humans.

We seek a highly motivated individual, with an ability to work independently and a strong interest in pursuing a PhD degree in medical microbiology. The expected starting date is spring 2025, or as otherwise agreed.

The research group where the candidate will work studies heteroresistance and its mechanisms with a focus on how variations in gene copy number affect evolution of antibiotic resistance and horizontal gene transfer. The successful candidate will have access to a large collection of genetically well-characterized and clinically problematic bacteria (E. coli, S. enterica, and K. pneumoniae) that will be studied via experimental evolution, precise genetic constructions, ddPCR, Illumina and Nanopore sequencing as well as proteomics and RNA seq. The position is one of 10 PhD positions in the new Horizon Europe-funded Marie Skłodowska-Curie Action (MSCA) Doctoral Network ENDAMR.

Examples of recent publications that the project is based on are:

  • Nicoloff H et al (2019). The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification. Nature Microbiology. 4: 504.
  • Andersson DI et al (2019). Mechanisms and clinical relevance of bacterial heteroresistance. Nature Reviews in Microbiology. 17:479.
  • Pal A and Andersson DI (2024). Bacteria can compensate the fitness cost of amplified resistance genes via a bypass mechanism. Nature Communications, 15:2333.
  • Nicoloff H et al (2024). Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance. Nature Communications. 15:3981.
  • Heyman G et al (2025). Prevalence, misclassification and clinical consequences of the heteroresistant phenotype in E. coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study. Lancet Microbe, Jan 16:101010.

Duties

The successful candidate will primarily engage in research work and doctoral studies. Other duties at the department may include administration and teaching, at a maximum level of 20%.

Requirements

  • Hold a Master's (second-cycle) degree in Genetics, Microbiology, Evolutionary Biology, or a related field, or
  • Have completed at least 240 credits in higher education, with at least 60 credits at Master's level including an independent project worth at least 15 credits, or
  • Have acquired substantially equivalent knowledge in some other way.

We are looking for a candidate who has laboratory experience in molecular biology, bacterial genetics, and microbiology. Very good oral and written communication skills in English are required. Emphasis will also be given to personal qualities such as collaboration and communication skills as well as analytical capacity. The ability to take own initiatives as well as to work well independently and in interaction with other research groups is an asset.

Additional qualifications

Working knowledge in bioinformatics is a merit.

About the employment

The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment is 100%. The salary is €3078 before tax, including a mobility allowance of €600 and possible family allowance of €660. Starting date as soon as possible or as agreed. Placement: Uppsala.

Please submit your application by April 30, 2025, UFV-PA 2025/538.

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