Scientist/Senior Scientist in vitro immuno-oncology, RNA-based therapeutics

1 week ago

Lund, Skåne, Sweden Asgard Therapeutics AB Full time

Asgard Therapeutics is a spin-off from Lund University, Sweden, aiming to advance cancer immunotherapies by harnessing direct cell fate reprogramming technologies. Our lead program, AT-108, is a adenovirus-based gene therapy that reprograms cancer cells into antigen-presenting dendritic cells, unleashing the immune system against cancer. Asgard is expanding its multidisciplinary team that understands the value and opportunities of working in a startup based in a unique platform technology. We are looking for candidate who are creative and passionate about making a contribution to the cancer immunotherapy field and improve patients' lives.

Position overview

We are seeking a highly enthusiastic and innovative Scientist/Senior Scientist searching for an opportunity to help building an early-stage company and contribute to the development of next generation cancer immunotherapies. The successful candidate should have the ability to design experiments autonomously, analyze complex data, troubleshoot technical issues, and supervise junior staff. Strong interpersonal, verbal and written communication skills are required. Experimental rigor, scientific curiosity and ability to work in a fast-paced environment, adapting to evolving priorities are musts. The position will be lab-based and research activities will be performed in collaboration with the Cell Reprogramming in Hematopoiesis and Immunity Lab at Lund University ).

Profile

Scientist/Senior Scientist with background in tumor immunology to work in the experimental validation of non-viral vectors to validate cDC1 reprogramming efficacy ex vivo. The candidate will test RNA-based platforms to deliver reprogramming factors and explore potential optimizations to the vector. The ideal candidate should have a Ph.D. degree in an immunology-related field with relevant in vitro laboratory experience in academia or biotech industry.

Responsibilities

  • Drive innovative research on in vitro and in vivo non-viral direct reprogramming modalities, with particular focus on dendritic cell reprogramming and tumor targeting.
  • Evaluate RNA based platform ex-vivo efficacy in human monolayer models in terms of cDC1 reprogramming efficiency.
  • Develop functional and analytical methods to characterize RNA-based vectors.
  • Design, plan, and execute scientific experiments autonomously to complete program and company goals within designated timelines.
  • Collect and document primary data to maintain up to date records.
  • Analyze, summarize data in reports and communicate outputs to Asgard's R&D and executive leadership team.

Qualifications:

  • PhD in Biomedicine, Cell Biology, Immunology, Cancer Biology or related field, with 0-5 years of post-graduation experience in academic or industrial environment. Applicants within 2-years after completing their PhD studies are encouraged to apply.
  • Experience with general in vitro 2D cell culture techniques.
  • Experience in the development and application of tumor biology-related in vitro assays, including multi-color flow cytometry for immune profiling, FACS, T-cell cytotoxicity assays, complex cell-based functional assays (such as antigen presentation and cancer cell cytotoxicity).
  • Experience in RNA biology and development of RNA-based gene therapy vectors, molecular cloning, vector production, encapsulation in nanoparticles and in vivo delivery is a plus.
  • Previous experience in in vivo/in situ gene therapy and cell reprogramming is a plus.

Literature:

  • Zimmermannova O, Ferreira A, Ascic E, Santiago M, Kurochkin I, Hansen M, Met Ö, Inês Caiado I, Shapiro I, Michaux J, Humbert M, Soto-Cabrera D, Benonisson H, Silvério- Alves R, Gomez-Jimenez D, Bernardo C, Bauden M, Andersson R, Höglund M, Miharada K, Nakamura Y, Hugues S, Greiff L, Lindstedt M, Rosa F, Pires C, Bassani-Sternberg M, Svane I, Pereira CF. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd
  • Rosa FF, Pires CF, Kurochkin I, Halitzki E, Zahan T, Arh N, Zimmermannová O, Ferreira AG, Li H, Karlsson S, Scheding S, Pereira CF. Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Sci Immunol. 2022 Mar 4;7(69):eabg5539.
  • Zimmermannova O, Caiado I, Ferreira AG and Pereira C-F Cell Fate Reprogramming in the Era of Cancer Immunotherapy. Immunol. 12: doi: /fimmu
  • Pires CF, Rosa FF, Kurochkin I and Pereira C-F Understanding and Modulating Immunity With Cell Reprogramming. Front. Immunol. 10:2809. doi:10.3389/fimmu
  • Rosa FF, Pires CF, Kurochkin I, Ferreira AG, Gomes A, Palma LG, Shaiv K, Solanas L, Azenha C, Papatsenko D, Schulz O, Reis e Sousa C, Pereira CF. Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells. Science Immunology 2018, 7,

Application:

Please email your CV, cover letter and contact information for two references to to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.


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